I was skeptical of these, but the reviews were very good and I caught them on sale. First of all You get 256 patches in this box, that are 100% natural. You get 16 applications and they're so easy to apply. I apply them at night and sleep in them. After just 3 nights, there was a significant difference. My face is much smoother and the fine lines have disappeared. I like everything about these and would buy again.